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阿昔洛韦的改良合成法

An Improved Synthesis of Acyclovir

  • 摘要: 阿昔洛韦(无环鸟苷,acyclovir)是有效的抗病毒药。化学名为9-(2-羟乙氧基)甲基鸟嘌呤(1)。该药在体外对Ⅰ型及Ⅱ型单纯疱疹及带状水豆病毒高度有效,而对哺乳动物宿主

     

    Abstract: The present paper deals with an improved synthesis of acyelovir from guanine by aeetylation, condensation and hydrolysis with overall yield being 69.50%.

     

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