林可霉素氯代反应的改进
An Improved method for the Chlorination of Lincomycin
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摘要: 林可霉素的C-7(R)-OH经氯代反应后可得C-7(S)-Cl化合物,即克林霉素(Clindamycin)。其抗菌活性比林可霉素高4—8倍
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关键词:
- 林可霉素 /
- 氯代 /
- 克林霉素 /
- Vilsmeie-Haack试剂
Abstract: A new method for the chlorination of lincomycin is described. Lincomycin was chlorinated by Vilsmeier-Haack Reagent instead of by Rydon Reagent. Clindamycin obtained from this method was improved both in its quality and yield.-
Keywords:
- Lincomycin /
- Chlorination /
- Clindamycin /
- Vilsmeier-Haack Reagent
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