林可霉素氯代反应的改进
An Improved method for the Chlorination of Lincomycin
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摘要: 林可霉素的C-7(R)-OH经氯代反应后可得C-7(S)-Cl化合物,即克林霉素(Clindamycin)。其抗菌活性比林可霉素高4—8倍Abstract: A new method for the chlorination of lincomycin is described. Lincomycin was chlorinated by Vilsmeier-Haack Reagent instead of by Rydon Reagent. Clindamycin obtained from this method was improved both in its quality and yield.