诺氟沙星注射液中沉淀物的分析

Identification of the Unknown Precipitate Found in the Norfloxacin Injections

摘要: 采用紫外、红外、质谱和核磁共振等现代分析手段,对诺氟沙星注射液中的沉淀物进行了研究,确定该沉淀物为诺氟沙星的脱羧产物,并对产生沉淀的原因进行了分析,对诺氟沙星注射液以及喹诺酮类其它药物的质量控制有指导意义。

Abstract: The unknown precipitate found in the Norfloxacin Injections was analysed by modern analytical methods such as UV, IR, MS and NMR and was identified to be decarboxylate of norfloxacin. The cause of the formation of the precipitate was investigated. This is