吡喹酮涂剂的处方设计和体外筛选模型

The Formula Design and the Screen Model in Vitro for Praziquantel Spray

摘要: 在血吸虫病疫区使用护肤涂剂以防尾蚴感染,是血防工作的重要课题。几十年来曾筛选过大量配方,建立过多种活体筛选模型,然未能投入实用。提示筛选的三个环节即:高效主药、合理配方和筛选模型缺一不可。吡喹酮问世以后,已被国内外公认为最好的抗血

Abstract: The drug dissolution instrument and thin-layer chromatography were used as the main detective method for the establishment of a simplified model. The latter was employed in search of water-resisting skincare formula. 18 formulas of praziquantel spray, whi