四种小檗胺衍生物与红细胞膜Ca~(2 )-Mg~(2 )-ATPase的相互作用

基金项目: 国家自然科学资金资助项目

Interaction of Four Berbamine Derivatives with Erythrocyte Membrane Ca~(2 )-Mg~(2 )-ATPase

摘要: 四种小檗胺衍生物对人红细胞膜Ca~(2 )-Mg~(2 )-ATPase的基础活性无影响,但对钙调素(CaM)和胰蛋白酶限制性酶解这两种形式所活化的Ca~(2 )-Mg~(2 )-ATPase都有不同程度的抑制作用,且有平行的抑制强度。初步探讨了这类化合物影响Ca~(2 )-Mg~(2 )-ATPase活力的可能机制。
- 小檗胺衍生物 /
- 钙调素 /
- 红细胞膜Ca~(2 )-Mg~(2 )-ATPase /
- 限制性酶解
Abstract: The effects of four berbamine derivatives on the activity of basal-, CaM- and trypsin-stimulated Ca~(2 )-Mg~(2 )-ATPase were detected. The results showed these berbamine derivatives could not inhibit the basal activityof Ca~(2 )-Mg~(2 )-ATPase, but could
- Berbamine derivative /
- Calmodulin /
- Erythrocyte membrane Ca~(2 )-Mg~(2 )-ATPase /
- Limited trypsinization