双氯灭痛缓释片的初步研制

Preliminary Study on Diclofenac Sodium Sustained Release Tablet

摘要: 以壳聚糖作为缓释剂,通过湿颗粒压片法,制备了双氯灭痛缓释片。采用萃取紫外法,测定了家兔单剂量口服片(液)后血清中的双氯灭痛浓度,经计算机嵌合求得药动学参数,结果表明:缓释片的体内过程符合一室模型,并且体内外相关性良好,消除半衰期显著延长。

Abstract: Using claitosan as sustained release agent, the diclofenac sodium sustained release tablet (DSSR) by wet-granule compressing was prepared. The serum concntration of diclofenac was measured by extraction-ultraviolet spectroscopy after oral administration o