壳聚糖对灰黄霉素的助溶作用

The Effect of Chitosan on Dissolution Properties of Griseofulvin

摘要: 讨论了壳聚糖(chitosan)对灰黄霉素(GRF)的助溶作用,发现壳聚糖脱乙酰化程度的不同对GRF的助溶作用也不同,而壳聚糖分子量的大小对助溶作用并无显著影响,结果表明壳聚糖对GRF的助溶作用主要是通过分子间的缔合作用而造成。

Abstract: The enhancement of dessolution of Griseofulvin (GRF) from ground mixture with chitosan was investigated. The results showed that the dissolution rate of GRF increased greatly with the deacylation degree of chitosan. While was not significantly affected by