达到预期血药浓度的一种正弦给药方案设计

Design of A Sinusosidal Infusion Segiemens to Achieve A Predetermined Plasma Drug Level Range

摘要: 某些疾病的病情呈周期性变化，这已导致人们对周期性给药方法的研究，结果表明在某些情况下可提高疗效。本文通过对二房室模型的分析，得出在正弦输入方式下调节最初的给药时间可获得最佳疗效的方案。

Abstract: It is known that some disease state are in a cyclic manner which has resulted in cyclically varying drug treatment studies. Consequently ,cyclically varying drug treatment has demonstrated that it could improve therapeutic response in some cases. For two-