炎痛喜康贴剂制备及体外透皮吸收研究

Preparation of Piroxicam Transdermal Patch and Its In Vitro Evaluation

摘要: 研究了炎痛喜康贴剂的制备及其透皮吸收过程。透皮装置采用改进型Ｆｒａｎｚ扩散池。炎痛喜康能从贴剂中缓慢释放，在扩散介质中维持２４ｈ的恒定释药浓度。其平均透皮速率及平均透皮百分率分别与贴剂的处方配比、促渗剂含量、表面粘性、皮肤状况、工艺差异有关，而与贴剂的剥离粘性、含量差异无规律性联系。

Abstract: The article studied the transdermal formulation of piroxicam. Piroxicam adhensive patchs were prepared using Azone as a penetration enhancer. The transdermal flux of the patchs across rabbit skin in vitro was investigated by modified Franz diffusion cells