复方降糖口服液的药理研究

Pharmacological Research of Compound Antidiabetic Oral Liquid

摘要: 复方降糖口服液７．２，１４．４，２８．８ｇ／ｋｇ给小鼠连续ｉｇ１０ｄ，对正常小鼠血糖无明显影响；对由四氧嘧啶所致的糖尿病小鼠有明显降血糖作用；并可对抗由肾上腺素引起的小鼠血糖升高。该口眼液小鼠ｉｇ最大耐受剂量为２００ｇ／ｋｇ，长期毒性试验表明，口服液连续ｉｇ６０ｄ（９，１５，３０ｇ／ｋｇ·ｄ）对小鼠的饮食，行为活动，生长发育，血象，肝、肾功能及主要脏器无明显影响。

Abstract: The Compound Antidiabetic Oral Liquid(CADOL)(7.2,14,28.8g/kg ig for 10d) was evidenced to have no effect obviously on blood glucose level of normal mice(P>0.05),but to have the significant hypoglycemic activity on blood glucose level of alloxan diabetic m