氮酮对延胡索浸膏经皮给药的影响

Effect of Azone on Penetration of Rhizoma corydalis Extraction through Rat Skin

摘要: 研究了不同浓度氮酮对延胡索浸膏中延胡索乙素透皮吸收的影响，结果显示不同浓度的氮酮对延胡索乙素的促透作用在稳态呈线性关系，２％氮酮具最大促进作用，８ｈ延胡索乙素的累积透过量增加了１７％，稳态流量提高了５．７倍。实验中采用了一阶导数光谱法，以延胡索乙素为指标，比较延胡索的透过量，消除了皮肤对测定的干扰。

Abstract: The effect of varying concentrations of Azone was evaluated by measuring the penetration of Rhizoma corydalis extraction through rat skin using in vitro.The results showed that enhancing permeative function of Azone presented linearing at steady-state.Azo