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复方美沙芬片的HPLC分析

Determination of Dextromethorphan Hydrobromide,Pseudoephedrine Hydrochloride and Chlorpheniramine Meleate in Compound Dextromethorphan Tablets by HPLC

  • 摘要: 对新药复方美沙芬片中美沙芬、盐酸伪麻黄碱和扑尔敏的HPLC分析进行了研究,考察了流动相组成、pH等对分离的影响情况。以盐酸萘甲唑啉为内标,检测波长为265nm,在所测范围内,峰面积与被测物浓度的线性关系良好。美沙芬、盐酸伪麻黄碱和扑尔敏平均回收率分别为98.92%,98.73%和98.45%,RSD〈1.02%(n=5)。

     

    Abstract: A sensitive and simplified high performance liquid chromatographic procedure was develoed to determine dextromethorphan hydrobromide,pseudoephedrine hydrochloride and chlorpheniramine meleate in Compound Dextromethorphan Tablets.Naphazoline hydrochloride

     

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