中间体氨化物的纯度及其对氨氯吡咪原料药质量的影响
Purity of Intermediate Ammoniate and Its Influence on Quality of Amiloride
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摘要: 应用高效液相色谱考察了用于制备氨氯吡咪的中间体３，５－二氨基－６－氯－２－甲氧基－羰基吡嗪（氨化物）的纯度。色谱含量分析与熔点测定结果相互支持，氨化物含量高的粗品有高的熔点。用较高纯度的氨化物制备的氨氯吡咪的质量较高。Abstract: The Purity of 3,5-diamino-6-chlor-2-methoxy-carboyl-pyrazinge(ammoniate),an intermediate of amiloride was examined by HPLC.The chromatographic determination results of crude ammoniates conformed to melting point data.Ammoniate of high purity possessed hig
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