蛙皮活性提取物的抗炎作用和体外抗菌活性研究

Antinflammatory Effect and Antimicrobial Activity(in Vifro)of the Active Extracts from Rana guenfberi Skin

摘要: 从美国沼泽绿蛙的皮中分离、提取得到蛙皮活性提取物，体外抗菌试验表明，该活性提取物对金黄色葡萄球菌等有抑制作用。另外，小鼠分别ｐｏ０．２２ｇ／ｋｇ和０．４５ｇ／ｋｇ活性提取物，能明显降低致炎剂导致的小鼠耳肿胀率，分别比空白组降低１８．３％和３１．６％；能明显抑制小鼠血管通透性，Ａ５９０ｎｍ吸收值分别比空白组降低２３．４％和２４．３％。

Abstract: The active substances were separated from hona guentheri skin(RGAE).RGAE decreased the ear swelling caused by xylene and peritoneal permeability ind uced by acetic acid in mice. With the doses of 0.22 and 0.45 g/kg by po administration,the swelling rate w