气相色谱法测定人血浆中阿替洛尔含量
Determination of Atenolol in Human Plasma by Gas Chromatography
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摘要: 建立了人血浆中阿替洛尔气相色谱测定方法。提取样品经三氟乙酰化,电子捕获检测器检测,最低检测浓度可达5ng/ml。方法回收率大于93%,日内、日间RSD分别为2.5%和4.5%,血药浓度在50 ̄200ng/ml呈线性关系,r=0.99836,n=7。Abstract: The method for determination of atenolol in human plasma by gas chromatography was established. After being extracted from plasma,atenolol is trifluoracetated,and determined by gas chromatography using electron-capture detector(ECD). The lowest determinab