盐酸溴己新胶囊剂制备及体内药动学
Studies on Formulation and Pharmacokinetics in Man of Bromhexine Hydrochloride Capsules
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摘要: 制备了盐酸溴己新（ＢＨ）胶囊剂，比较自制胶囊剂与市售片剂的溶出度，建立ＢＨ体内分析方法，即用气相色谱－电子捕获检测法（ＧＣ－ＥＣＤ）测定ＢＨ的血药浓度，并进行药动学及生物利用度分析。Abstract: Bromhexine hydrochloride capeules we re prepared with suita ble excipients and technology.A method for dissolution testing was established to compare the capsules and commercially available tablets in vitro.The GC-ECD method was adapted to determine the p
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