3,5-二异丙基水杨酸及其铜络合物对水溶液和人血清中谷胱甘肽化学调节和代谢的作用
The Efect of 3,5-Disopropylsalicylic Acid and Its Copper Complex on Glutathione Chemical Modulation and Metabolism in Aqueous Solution and in the Serum Fraction of the Human Blood
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摘要: 应用分光光度法研究了3,5-二异丙基水杨酸(3,5-DIPS)及其铜(Ⅱ)络合物四(3,5-二异丙基水杨酸)二水二铜(Ⅱ)[Cu(Ⅱ)2(3,5-DIPS)4(H2O)2]对水溶液和人血中血清谷胱甘肽存在状态的影响。和对照组相比,3,5-二异丙基水杨酸存在时血清中硫酸水平较高,原因是其引起血液中更可能是血液蛋白中硫醇的泄漏。四(3,5-二异丙基水杨酸)二水二铜(Ⅱ)以剂量依赖方式增加血清中硫醇水平,但其铜络合物作用比3,5-二异丙基水杨酸更强。
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关键词:
- 谷胱甘肽 /
- 3,5-二异丙基水杨酸 /
- 四（3,5-二异丙基水杨酸）二水二酮（Ⅱ） /
- 化学调节 /
- 代谢
Abstract: The effect of 3,5-diisopropylsalicylic acid(3,5-DIPS) and its copper complex tetrakis-μ-3, 5-diisopropylsalicyla todiaquo dicopper(Ⅱ)Cu(Ⅱ)2(3,5-DIPS)4(H2O)2 on the status ofglutathione(GSH) in a queous solution and in the serum fraction of the human blood has been studied using spectrophotometric method. Glutathione in aqueous solution was oxidized in the presence of both (3,5-DIPS) and Cu(Ⅱ)2(3,5-DIPS)4(H2O)2 due to the air oxidation o f GSH to GSSG. The addition of 3,5-DIPS to the serum fraction of the human blood caused leakage of GSH, more likely from the albumin, giving higher GSH levels than control. Cu(Ⅱ)2(3,5-DIPS)4(H2O)2 increased the the serum GSH levels more effectively and in dose dependent manners. This observationisin agreement with the previous reports that copper complexes of chemicals and/or drugs are more effective in treating various diseases and are better active scavangers offree radicals than the parent chemicals and/or drugs. -
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