头孢呋新酯的多晶型研究

Investigation of the Polymorphism of Cefuroxime Axetil

摘要: 用不同有机溶剂重结晶制备了头孢呋新酯的多晶型，通过差热分析、红外光谱、Ｘ－射线粉末衍射法等进行鉴别，确定头孢呋新酯的晶体存在两种晶型，即低熔点晶型α和高熔点晶型β。测定了不同温度下，两晶型在０．０７ｍｏｌ／Ｌ盐酸溶液中的平衡溶解度，并计算其溶解热。
- 头孢呋新酯 /
- 多晶型 /
- 差热分析 /
- 红外光谱 /
- X-射线粉末衍射 /
- 溶解热
Abstract: The polymorphs α and β of cefurox ime ax etil were prepared from different organic solvents and characterized by means of DSC、IR and X-ray powder diffraction. Equilibrium solubilities were measured at five different temperatures in 0. 07 mol /L HCl solution and the enthalpies were calculated. The solubilities of crystal form α at fiv e different tempertures in 0. 07 mo l /L HCl solution were greater than those of crystal form β. The enthalpies of crystal form α and β were 9. 64 kJ/mol and 12. 04 k J/mol, respectively.
- Cefuroxime axetil /
- Polymorphism /
- DSC /
- IR /
- X ray powder diffraction /
- Enthalpy