Enhancing　Effect　of　Geraniol　on　the　Permeation　of　5-Fluo-rouracil　Through　Excised　Rat　Skin

Enhancing Effect of Geraniol on the Permeation of 5 Fluorouracil Through Excised Rat Skin

摘要: 研究香叶醇（３，７－二甲基－２，６－辛二烯－１－醇）作为５－氟脲嘧啶的透皮促进剂，表明香叶醇的促进作用弱于阿佐恩。两者分别可使药物渗透系数增加４８．３０和８２．８２倍。与阿佐恩相似，香叶醇增加药物的分配系数，也增加其扩散系数值。可以认为该促进剂的作用方式是影响分配和扩散过程，其中扩散过程是主要因素。

Abstract: Geraniol(3,7 dimethyl 2,6 octadiene 1 ol) was evaluated as penetration enhancer towards 5 fluorouracil(5 FU) using excised rat skin Azone was used for comparison The enhancing effect of geraniol was found to be less than that of Azone Geranio