苯骈吡喃肟类化合物的合成及生物活性

Synthesis and Bioactivity of Benzopyran 4 one Oximes

摘要: 苯骈吡喃类钾通道启开剂作为抗高血压药物正日益引人注目。根据现有构效关系，运用经典的药物设计方法，设计合成了２８个苯骈吡喃肟类化合物。初步药理研究表明，某些化合物有一定程度的扩血管活性。

Abstract: Considerable attention is being given to the potassium channel openers of benzopyrans as potential therapeutical agents for hypertention Based on the structure activity relationships reported in the literatures and applying the classic theory of drug d