N—酰化苄基四氢异喹啉类化合物的合成及其抗血小板聚集活性
Synthesis and Antiplatelet Aggregation of N Acylated Tetrahydrobenzylisoquinoline
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摘要: 合成了14个N-酰化苄基四氢异喹啉化合物,并选择其中10个化合物做了抗血小板聚集作用的体外试验,结果发现多数均具有一定的活性,为今后该类化合物的研究提供了参考数据。Abstract: Fourteen N acylated tetrahydrobenzylisoquinoline derivatives were designed and synthesized of which 13 were not reported previously. The preliminary pharmacological tests showed that most compounds exhibited various degrees of antiplatelet aggregati