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头孢哌酮合成工艺的改进

Improvement on Synthesis of Cefoperazone

  • 摘要: 以7-ACA为起始原料,经与1-甲基四氮唑-5-硫醇缩合,再与D-(-)-2-(4-乙基-2,3-二氧代-1-哌嗪酰胺)-2-(4-羟基-苯基)-醋酸缩合得头孢哌酮。方法A和方法B的总收率分别为38.2%和34.2%。

     

    Abstract: Cefoperazone was synthesized in two steps. The synthetic method, especially the subsequent disposal method,was improved by recrystallization from mixed solvent of acetonitrile and water. The overall yield of method A and method B were 38.2% and 34.2% res

     

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