苯骈吡喃酮肟类化合物的生物活性及定量构效关系研究
Studies on the Bioactivity and QSAR of Some Benzopyran 4 one Oximes
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摘要: 根据苯骈吡喃类钾通道启开剂的构效关系，设计合成了１６个苯骈吡喃酮肟类化合物，测试体内外生物活性，并用逐步判别分析方法研究了该类化合物的构效关系Abstract: Benzopyran 4 one oximes were synthesized and evaluated for their bioactivity in vivo and in vitro QSAR was studied by stepwise discriminant analysis on the basis of the calculated structural parameters and bioactivity of vasodilation in vitr
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