化学酶法合成D—对羟基苯甘氨酸
Chemoenzymatic Synthesis of D p Hydroxyphenylgycine
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摘要: 采用乙二醛、苯酚和尿素为原料化学合成底物DL-对羟基苯乙内酰脲。以沟槽假单孢菌CPU1628或放线形土壤杆菌CPU1211为酶源,将DL-对羟基苯乙内酰脲生物转化为D-对羟基苯甘氨酸,产率分别为86%和80%。Abstract: A simple and economical method of chemoenzymatic synthesis of D p hydroxyphenylgycine was developed The substrate DL p hydroxyphenylhydantoin was synthesized in a chemical process from glyoxal,phenol and urea D p hydroxyph