喹诺酮类抗菌剂抗分支杆菌的QSAR研究——C-7位结构变化对活性的影响

基金项目: 国家自然科学基金

Studies on the Quantitative Structure activity Relationship of the Quinolone Antibacterials Against Mycobacteria:Effect of Structural Changes at C 7

摘要: 用分子连接性指数法对一系列喹诺酮类化合物抗结核病分支杆菌的定量构效关系进行了研究。设计了４个新的化合物，预测它们具有高的抗菌活性。
- 喹诺酮 /
- 分支杆菌 /
- 分子连接性 /
- 定量构效关系
Abstract: The quantitative structure activity relationship(QSAR) of the quinolone antibacterials against mycobacteria was studied by the method of molecular connectivity. Four compounds were designed, which were expected to have high antibacterial activity aga
- Quinolone /
- Mycobacterium fortuitum /
- Molecular connectivity /
- Quantitative structure activity relationship(QSAR)