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降糖药格列美脲的合成工艺研究

Studies on Synthesis of Antidiabetic Glimepiride

  • 摘要: 以乙酰乙酸乙酯为起始原料,经八步反应制得新降糖药格列美脲(glimepiride) ,总收率为11 .5 % ,反应原料易得,反应条件温和,后处理方便,适合工业化生产。

     

    Abstract: Antidiabetic glimepiride is pharmacologically distinct from other sulfonylureas with a profile of potent and long lasting blood glucose lowering effect. Glimepiride was synthesized via eight steps with ethyl acetoacetate as starting material. The total y

     

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