盐酸曲马多缓释胶囊的制备及药动学研究
Studies on the Sustained-Release Microtablet Capsule of Tramadol and Its Human Pharmacokinetics
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摘要: 研制了盐酸曲马多缓释微片胶囊,研究了其人体内药物动力学。其体外释放行为符合一级动力学过程,体内配置状态以一室模型描述较为适宜。药动学参数为Ka=0.4864h-1,K=0.0898h-1,Cmax=234.3ng／ml,Tmax＝5.7h,AUC0→∞（ng／ml·h）＝4244.38
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Keywords:
- Tramadol /
- Sustained-release capsule /
- Pharmacokinetics
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