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溴莫普林的合成

Synthesisof Brodimoprim

  • 摘要: 以 4 溴 3,5 二羟基苯甲酸为起始原料 ,经甲基化 酯化、肼化、氧化得 4 溴 3,5 二甲氧基苯甲醛 ,与丙烯腈缩合 ,再与硝胍环合得标题化合物 ,总收率为 2 9%。

     

    Abstract: An improved process for the preparation of brodimoprim(1) was described. Compound 1 was synthesized from 4 bromo 3,5 dimethoxy benzoic aldehyde(5) by condensation with acrylonitrile and cyclization with guanidine nitrate. The compou

     

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