聚乳酸酮洛芬微球的制备及其体外释放度
Preparation and In vitro Release of Polylactic Acid Microspheres Containing Ketoprofen
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摘要: 制备了生物可降解的材料聚乳酸，用粘度法测定其分子量，并选用Ａ、Ｂ、Ｃ三种不同分子量的聚乳酸为药物的载体，制备了酮洛芬微球（ＡＳ，ＢＳ，ＣＳ），测定其粒径和体外溶出速率。结果表明催化剂四苯基锡用量增加，所得的聚乳酸分子量增加，而制备酮洛芬微球的聚乳酸分子量越大，其微球粒径越大，溶出速率越小。Abstract: Three batches of polylactic acid (PLA) were prepared from lactic acid using tetraphenyl tin as a catalyst.Their molecular weights were evaluated by viscosimetry. PLA microspheres containing ketoprofen were made by the oil/water solvent evaporation process
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