使用微粉化技术改善头孢呋新酯片的溶出

Dissolution Improvement of Cefuroxime Axetil Tablets by Using Micronization Technology

摘要: 为改善头孢呋新酯的溶出，采用气流粉碎球磨、重结晶、固态分散技术等多种微粉化技术，通过差热分析和Ｘ衍射研究微粉化后头孢呋新酯的晶型特征。结果表明，固态分散技术可使该药由晶型转变为无定型，从而大大增加其生剂的溶出。溶解热的计算进一步证明了这一结果。

Abstract: In order to improve the dissolution of cefuroxime axetil, we used several types of micronization technology: air jet micronization, ball mill grinding, recrystallization, co precipitate. Crystal properties of cefuroxime axetil after micronization were