铂类抗癌药物体内药物浓度的电热原子吸收光谱分析

The Determination of Concentration in Body of Platinum-based Anti-Cancer Drugs by Electrothermal Atomic Absorption Spectroscopy

摘要: 应用电热原子吸收光谱分析技术（ＥＡＡＳ）对血浆、尿液、胆汁及各种组织中的总铂的含量进行了测定。研究表明，经合理的原子化程序设定后，尿液和胆汁可以不加处理直接进样，血浆用０．２５％，ＴｒｉｔｏｎＸ－１００等量稀释，组织只采用简单快捷的均相酸消化法。本方法精密度ＲＳＤ〈１０％，回收率８７．４０％～１１０．０％，在０．０８～５．００μｇ／ｍｌ铂浓度范围一关系良好，相关系数ｒ〉０．９９６２适合于铂类药物药

Abstract: The improved methods for the determination of total platinum in a large number of different tissuses and body fluids by electrothermal atomic absorption spectroscopy were described.Urine and bile were analyzed without pretreatment. Plasma was analyzed aft