抗早产药利托君的合成

Synthesis of Ritodrine

摘要: 以苯酚为原料，经酰化，Ｆｒｉｅｓ重排、氧苄醚化、省化得中间体２－溴－１－对苄氨基苯丙瓣，再地甲氧基苯乙胺胺化、氢化脱苄基、４８％氢溴酸脱甲基、硼氢化钾还原共八步反应合成利托君。总收率（以苯酚计）为１４．１％。

Abstract: Ritodrine was prepared from phenol by acylating, Fries rearranging, etherifying with benzyl chloride, brominating, amination with 2 (4 methoxyphenyl)ethylamine, converting benzyloxy group into hydroxy group by hydrogenation, demethylation by 48% HBr and