盐酸非洛普对映体分离的核磁共振光谱拆分法
19FNMR Studies ofPhenoprolamine Hydrochloride Enantiomeric Excess
-
摘要: 制备盐酸非洛普的三氟乙酰化衍生物，在手性位移试剂Ｅｕ（ＨＦＣ）３作用下，核磁共４振氟谱产生了明显的对映体位移差值（该值最大为１８．０Ｈｚ），可利用这种拆分方法对直国酸非洛普测定其对映体相对含量。Abstract: Phenoprolamine hydrochloride was conversed into the N trifluoro acetyl phenoprolamine hydrochloride and determined enantiomeric excess by \ \19\FNMR with Eu(HFC)\-3. Optimisation of the experimental conditions led to two sets of enantiomrric reson
下载: