酸酐—酰亚胺共聚物的合成

Synthesis of Biodegradable Anhydride-co-imide Terpolymer

摘要: 熔融缩聚法合成了酸酐－酰亚胺共聚物并研究了基性质。酸酐－酰亚胺共聚物是一种新型的生物可降解高分子材料，它是在以癸二酸（ＳＡ）和１，３－双（对羧基苯氧基）己烷（ＣＰＨ）为单体的聚酸酐骨架中插入含有酪氨酸的单体（ＴＭＡ－Ｔｙｒ）而形成的。酪氨酸作为免疫佐剂可显著提高机体对吸收抗原的免疫应答，从而使酸酐－酰亚胺共聚物有可能成为一种极佳的免疫抗原载体。

Abstract: Polyanhydride composed of sebacic acid (SA), 1,3-bis( p -carboxyphenoxy)hexane (CPH) and N -trimellitylimido- L -tyrosine (TMA-Tyr) was synthesized by melt condensation polymerization. Tyrosine was incorporated into the polymer backbone due to its