手性修饰的硼氢化钠对前手性酮的不对称还原
Asymmetric Reduction of Prochiral Ketones Using Chirally Modified Sodium Borohydride
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摘要: 研究了以Ｎ－苄基－（３Ｓ，４Ｓ）－３，４－二羟基四氢吡咯修饰的硼氢化钠对前手性酮的不对称还原反应，合成了五个光学活性醇，同时研究了添加路易斯酸对还原反应光学产率的影响。Abstract: Optical active alcohols were prepared by one-step reduction of prochiral ketones using sodium borohydride modified by \%N\%-benzyl-(\%3S,4S\%)-3,4-dihydroxy pyrrolidine.The effect of adding Lewis acids on reduction was also studied.
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