来氟米特的合成研究
Studies on Synthesis of Leflunomide
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摘要: 以乙酰乙酸乙酯为起始原料,经五步反应制得来氟米特,总收率为43.6%,反应原料易得,反应条件温和,后处理方便,适合工业化生产。Abstract: Leflunomide was synthesized via five steps with ethyl acetoacetate as starting material. The total yield was 46.3%. The condition of reaction was mild and suitable for industry-scale manufacture.