缺血预处理对大鼠四动脉结扎后氧化应激及脑水肿的保护作 …

Ischemic Preconditioning is More Effective to Scavenge Oxidative Stress and Cerebral Edema Against Cerebral Infarct Size by Four-vessel Occlusion in Rats

摘要: 观察缺血预处理对大鼠四动脉结扎法的全脑缺血／再灌注损伤的保护作用。预处理后，缺血３０ｍｉｎ，再灌注１０及３０ｍｉｎ。记录并比较ＥＥＧ、ＭＤＡ、脑含水量和脑梗塞范围。脑缺血期间脑电波变平，缺血预处理减少脑电波的变化，并且减少梗塞范围。再灌注１０和３０ｍｉｎ后，对梗塞抑制率分别为２０％和５４％。缺血预处理也可将ＭＤＡ和含水量恢复到正常水平。预处理消除氧化应激反应和脑水肿，比减少脑梗塞范围更有效。

Abstract: To investigate the protective effect of preconditioning on global cerebral ischemic damage by 4-vessel occlusion model in rats. Preconditioning was established followed by 30 min ischemia and reperfusion for 10 and 30 min, separately. Data of EEG ampli