柱晶白霉素发酵工艺的代谢调控研究

Metabolism Regulation on Fermentation of Leucomycin

摘要: 柱晶白霉素（Ｌｅｕｃｏｍｙｃｉｎ，ＬＭ）是低毒有效的十六元大环内酯类抗生素，其生物合成受到前体及调节物的影响。本文研究了柱晶白霉素发酵工艺的代谢调控，探讨了前体及代谢调节物对抗生素效价的影响。实验结果表明在发酵开始前加入０．１％的前体丁酸钠及１％的调节物磷酸镁，效价分别比对照组提高了３３０％和２３０％，可为工业应用提供帮助。

Abstract: Leucomycins(LM) are 16-membered macrolide antibiotics with high activity and low toxicity. Biosynthesis of LM was greatly affected by precursor and regulator. The metabolism regulation on fermentation of LM was researched a nd the influence of antibioti