特比萘芬的合成

Synthesis of Terbinafine

摘要: 目的：研究抗真菌药特比萘芬的合成路线及工艺。方法：以频哪酮为起始原料，经氯代，脱所化氢，格氏反应得6，6－二甲基－1－庚烯－4－炔－3－醇（5），溴代后与N－甲基－1－萘甲胺反应得标题化合物。结果：合成了目标化合物，其结构经IR，^1HNMR,MS，元素分析得以确正。结论：合成路线及工艺较适用于工业化生产。

Abstract: AIM: To develop a modification of the general route for the synthesis of terbinafine. METHODS: Compound (1) was synthesized from 1 bromo 6,6 dimethyl 2 hepten 4 yne(6) by reaction with N methyl 1 naphthalenemethanamine. Compound 5 was prepar