2—(3—苯甲酰基苯基)丙腈的合成研究
Improved Synthesis of 2-(3-benzoylphenyl) propionitrile
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摘要: 目的:进行2-(3-苯甲酰基苯基)丙腈的合成研究,提高收率,降低二甲基副产物比例。方法:采用相转移催化法以硫酸二甲酯为甲基化剂进行α-甲基化反应,并采用适当的后处理方法。结果:反应主要控制在单甲基化阶段。且通过适当的后处理方法,可得产物含量较高的固体纯品,结论:相转移催化剂能有效控制反应在单甲基化阶段,且合适的后处理方法也能一定程度提高产品质量。Abstract: 2 (3 benzoylphenyl)propionitrile which is an important intermediate of ketoprofen was synthesized through phase transfer catalytic by four steps, involving Friedel crafts reaction, bromination and cyanation. Pure compound was obtained, and the content o