双氯芬酸钾缓释片的研制及释药特性的探讨

Development of Diclofenac Potassium Sustained-Release Tablets and Exploration of Released Character

摘要: 目的：研制凝胶骨架型双氯芬酸钾缓释片，考察缓释片体外释药特性。方法：以羟丙基甲基纤维素为主要凝胶材料，辅以疏水性阻滞剂以调节释放度，根据设计的体外释药速率，筛选处方。结果：药物释放系扩散机理控制，释药速率受pH环境影响，不受压片压力的影响，受机械撑动影响较小。结论：本文研制的双氯芬酸钾缓释片成型笥好，具工艺重现性，体外释放符合拟定的释药速率。
- 双氯芬酸钾 /
- 缓释片 /
- 释放度 /
- HPMC /
- 非甾体消炎镇痛药
Abstract: AIM\ Diclofenac potassium sustained release tablets were developed as a gel matrix for using twice daily and evaluated in vitro release characteristics. METHODS\ The formulations were screened according to the designed \%in vitro\% release rate by th
- Diclofenac potassium /
- Sustained-release tablet /
- Release /
- HPMC