侧柏叶醇提取物抗炎作用的研究
Study on theAnti-inflammatory Effect of Biota orientalis
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摘要: 目的：探讨侧柏叶醇提取物的抗炎机理。方法：以大鼠胸腔白细胞及兔血小板为材料。用高效液相色谱法测定细胞白三烯，12-羟十七碳三烯酸及12-羟廿碳四烯酸的生成，结果：侧柏叶醇提取物对白细胞内白三烯B4及5-羟廿碳四烯酸的生物合成有较强的抑制作用。其IC50值分别为含生药0.4mg/ml及生药0.41mg/ml，侧柏叶醇提取物还可显著抑制血小板12-羟十七碳三烯酸的生物合成。结论：侧柏叶醇提取物中含有较强的抗炎成分。其作用机制与抑制药生四烯酸的代谢有关。Abstract: AIM The purpose is to investigate the Anti inflammatory mechanism of \%Biota orientalis\%. METHODS Using rat leukocytes and rabbit platelets as experimental material the biosynthesis of leukotriene, 12 hydroxyheptadecatrienoic acid(12 HHT) and 12
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