瑞香苷对高尿酸血症小鼠的影响

Effects of Daphnin on Serum Uric Acid Level in in vivo Model of Hyperuricemic Mice

摘要: 目的；研究瑞香苷对高尿酸血症小鼠血清尿酸水平的影响。方法：选择化学诱导剂氧嗪酸钾盐作为尿酸酶抑制剂，小鼠腹腔注射后造成高尿酸血症模型，采用磷钼酸还原法测定小鼠血清尿酸水平。结果：腹腔注射瑞香苷（50，100和200mg/kg)能显著地减少高尿酸血症小鼠血清尿酸水平，具有一定的量效关系。瑞香苷100mg/kg剂量组作用时间可维持5h。瑞香苷在剂量为200mg／kg时可降低正常小鼠血清尿酸水平。结论：瑞香苷对高尿酸血症小鼠具有明显降低血清尿酸水平作用。

Abstract: AIM The purpose is to study hypouricemic effect of daphnin on serum uric acid level in hyperuricemic mice. METHODS The uricase inhibitor potassium oxonate was used to induce in \%in vivo\% model of hyperuricemia in mice. Serum uric acid level was dete