黄芪多糖硫酸酯的合成及其抗病毒活性研究
Synthesis and Antiviral Activity of Astragalus mongholicus Polysaccharide Sulfate
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摘要: 目的：制备黄芪多糖（PAM）硫酸酯，寻找具有优良抗病毒活性的物质。方法：将纯化得到的PAM，用硫酸化试剂氯磺酸－吡啶合成PAM硫酸酯（PAMS），采用体外抗病毒试验测定了PAMS对I型单纯疱疹病毒HSV－1的活怀。结果：制备了PAMS，在抑制HSV－1活性的试验中给药组与对照组（阿昔洛韦，ACV）之间有非常显著的差异。结论：PAMS有很强的抑制I型单纯疱疹病毒的活性，在相同浓度下，优于ACV。Abstract: AIM The purpose is to prepare \%Astragalus mongholicus\% Bunge polysaccharide sulfate (PAMS), and to search for the substance with high antivirus activity. METHODS PAM was obtained by reaction of purified \%Astragalus mongholicus\% Bunge polysaccharide
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