人参制剂中人参皂甙在大鼠小肠中的吸收
Absorption of Ginsenosides of Ginseng Preparations in Rat Small Intestine
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摘要: 目的：由于口服人参皂甙的生物利用度较小，本文研究了小肠对人参皂甙的吸收功能。方法：采用在体大鼠小肠吸收模型，以人参煎剂和人参总皂甙溶液剂作为灌流液。结果与讨论：在3小时中每只大鼠吸收的人参皂甙平均值分别为21.79mg和18．41mg。大鼠小肠对人参总皂甙溶液中人参皂甙 的吸收基本遵循动力学一级反应；对人参煎剂中人参皂甙的吸收在第二小时时受到阻滞。该结果显示大鼠小肠对人参皂甙具有正常的吸收功能，建议含人参制剂应能避免胃酸水解，并尽可能知小肠得到完全的吸收。Abstract: AIM Since bioavailability of ginsenosides is small by oral administration,the absorption of ginsenosides in the small intestine was studied.METHODS The absorption action was investigated in an in situ perfusion model of rat small intestine.A ginseng(roo
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