盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨
Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character
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摘要: 目的:探索固体自乳化释放药系统,研制自乳化缓释片,考察体外释药行为。方法:以盐酸维拉帕米(Verpamil Hydrochloride,VH)为模型药物,以吐温80(Tween80),豆磷脂(sbpc)为乳化剂,以羟丙甲纤维素(HPMC),卡波普(carbopol)为骨架材料,制备自乳化缓释片。结果:以含吐温80和豆磷脂10%,羟丙甲纤维素和卡波普30%的处方乳化效果好,体外释药符合要求。结论:通过调节乳化剂和骨架材料的比例,可以获得理想的自乳化固体缓释制剂。Abstract: AIM Self emulsifying drug delivery systems were studied. Verapamil Hydrochloride self emulsifying sustained release tablets were developed and evaluated \%in vitro\% release characteristics. METHODS The Verapamil Hydrochloride formulations were scre