香豆素磺酰脲类化合物的合成研究

Further Studies on the Preparation of Coumarin- 6- sulfonylureas

摘要: 目的合成新的香豆素磺酰脲类化合物供药理筛选。方法通过改进的方法合成芳香异氰酸酯中间体，再与磺酰胺反应合成目标化合物。结果和结论通过新的路线合成了18个香豆素磺酰脲类化合物（SU－22－39），所有目标化合物均未见文献报道，其结构经IR、^1HNMR和HRMS鉴定。进一步和降血糖活性研究正在进行。
- 降血糖 /
- 香豆素磺酰脲 /
- 异氰酸酯 /
- 合成
Abstract: AIM To prepare a serious new coumarin-6-sulfonylureas. METHODS An improved process for the preparation of arylisocyanates was described. The title compounds were synthesized from coumarin- 6-sulfonamides by reaction with arylisocyanates. RESULTS and CONCL
- Hypoglycaema /
- Coumarins-6-Sulfonylureas /
- Isocyanates /
- Synthesis