高效毛细管电泳法分离八种含氨基手性药物的对映体

Study on the Chiral Separation of Eight Amino-drugs by HPCE

摘要: 目的采用HPCE法拆分八种含氨基手性药物对映异构体。方法液中添加18－冠－6－四甲酸－18－Crown-6-(COOH)4（18C6H4），并且对18C6H4的浓度、缓冲液的pH值和浓度以及柱温等影响分离的因素作了系统的研究；检测波长210nm。结果八种含氨基手性药物对映体得以拆分。结论缓冲液中添加手性冠醚的HPCE法能较好地拆分伯胺类药物。

Abstract: AIM Chiral separation of drugs having a primary amino group was studied by high performance capillary electrophoresis(HPCE) using 18C6HA as chiral selector. METHODS Both complexation and resolution were affected by 18C6HA concentration, pH and concentrati