清开颗粒对急性肝坏死大鼠血清一氧化氮和肿瘤坏死因子的影响

Influence of Qingkai Granules on the Serum Nitric Oxide and Tumor Necrosis Factor in Rat with Acute Hepatic Injure

摘要: 目的观察清开颗粒对大鼠血清一氧化氮（NO）及肿瘤坏死因子（TNF）的影响，探讨清开颗粒抗急性肝坏死的作用机制。方法分别以D－GalN加LPS染毒和TAA染毒Wistar大鼠造成两种急性肝坏死动物模型。用Backman自动生化分析仪测试血清NO和TNF。结果清开颗粒治疗组和预防组的血清NO和TNF水平明显低于模型组和HGF对照组（P＜0.05）。结论清开颗粒有降低大鼠血清NO和TNF的作用，这可能就是清开颗粒抗急性肝坏死的作用机制之一。

Abstract: AIM To study the influence of Qingkai Granules on the serum Nitric Oxide and Tumor necrosis factor in rat with Acute Hepatic injure,and explose research the mechanism of Qingkai Granules (QKG) in treating Acute Hepatic injure. METHOD Experiment model of A