香豆素磺酰脲类化合物的降血糖作用研究

Hypoglycemic Effect of Coumarin-6-Sulfonylureas

摘要: 目的：对香豆素磺酰脲类化合物的降糖作用进行初步筛选；测定10个香豆素磺酰脲化合物的药效学参数。方法：正常小鼠灌胃给药后，毛细玻管取血，用葡萄糖测定法(GOD—PAP)测定血糖。结果和结论：初步药理实验表明SU—111，SU—118，SU—611，C6，SU—614，SU—615，SU—616等有明显降糖作用；测定了10个香豆素磺酰脲类化合物对正常小鼠降血糖作用的药效学参数，并用于构效关系分析。

Abstract: The purpose is to study the effect on serum glucose by giving diff erent coumarin 6 sulfonylurea compounds. Serum glucose of normal mice were determined after giving coumarin 6 sulfonyl urea compounds (50 mg/kg, ig) Results showed that the drugs inc